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David Lang

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David Lang

David Lang. Education; Publications; Presentations; Research; Awards; Projects; Employment; Blog. Ph.D Candidate Department of Education · Stanford University

NYT Opinionator Blog - David Lang

David Lang · About · Biography · Interviews · Writings · Press · Music · Events · Discography ... NYT Opinionator Blog. A Pitch for New Music. May 11, 2011.

Comparative efficacy and safety of biologics and systemic immunomodulatory treatments for chronic urticaria: Systematic review and network meta-analysis.

BACKGROUND Chronic urticaria is a common skin condition characterized by itchy wheals (hives), angioedema, or both, lasting for 6 weeks or more. Beyond antihistamines, multiple systemic treatments are available, but there is uncertainty regarding their comparative effects on chronic urticaria outcomes. OBJECTIVE We systematically synthesized the comparative benefits and harms of systemic treatments for chronic urticaria. METHODS As part of updating the AAAAI/ACAAI JTFPP chronic urticaria guidelines, we searched Medline, Embase, Central, Chinese Biomedical Databases (CBM), China National Knowledge Infrastructure (CNKI), Chinese Scientific Journal Database (VIP), and Wanfang from inception to February 4, 2025, for randomized trials addressing systemic immunomodulatory treatments, including phototherapy, for chronic urticaria. Paired reviewers screened records, extracted data, and assessed risk of bias. Random effects Bayesian network meta-analyses addressed urticaria activity (comprising itch and wheal scores), angioedema activity, health-related quality of life, and adverse events. The GRADE approach informed certainty-of-evidence ratings (PROSPERO: CRD42023429819). RESULTS We included 93 studies (n = 11,398; mostly adult and adolescent participants across 83 randomized trials and 10 nonrandomized studies) that evaluated 42 interventions. With high certainty, standard-dose omalizumab (300 mg every 4 weeks) and remibrutinib are among the most effective for improving multiple patient-important outcomes. The safety profile of remibrutinib, however, is less certain. Dupilumab improved urticaria activity, but its impact on quality of life is uncertain, and no dupilumab trials addressed angioedema activity. Cyclosporine may be among the most effective for improving urticaria activity but may be among the most harmful in increasing the frequency of any adverse events. Azathioprine, dapsone, hydroxychloroquine, mycophenolate, sulfasalazine, and vitamin D may improve outcomes, while benralizumab, quilizumab, and tezepelumab may not differ from placebo, though the evidence is uncertain. Findings were consistent across age groups and baseline severity, and were robust to subgroup analyses. CONCLUSIONS Among individuals with chronic urticaria refractory to antihistamines, standard-dose omalizumab and remibrutinib are among the most effective drugs across multiple patient-important outcomes with a favorable safety profile across the studied duration. Cyclosporine may be effective but may be among the most harmful. Dupilumab improves itch and wheals, but it is uncertain whether it improves angioedema or quality of life. Lower doses of omalizumab are of intermediate effectiveness and favorable safety. The net benefit of conventional immunosuppressants is uncertain.

Patient Values and Preferences in Chronic Urticaria Treatment: A Systematic Review.

Importance Patient and caregiver values and preferences should inform clinical management. An update to the American Academy of Allergy, Asthma & Immunology/American College of Allergy, Asthma and Immunology's Joint Task Force on Practice Parameters guidelines on chronic urticaria (CU) plans to incorporate them; however, a systematic review of evidence on the values and preferences of patients with CU and their caregivers has not been previously available. Objective To synthesize patient and caregiver values and preferences regarding CU treatment options. Evidence Review A systematic search was conducted of MEDLINE, Embase, PsycINFO, and CINAHL databases, from inception to May 15, 2025, for studies addressing patient and/or caregiver values and preferences for CU management. Paired reviewers independently screened studies, extracted data, and assessed risk of bias. Thematic and inductive content analysis was used to qualitatively synthesize findings and certainty of evidence was rated per the Grading of Recommendations Assessment, Development and Evaluation-Confidence in the Evidence from Reviews of Qualitative Research approach. Findings The search resulted in 18 studies addressing the values and preferences among 28 497 participants. Moderate certainty evidence showed that patients were likely to place a high value on rapid improvement (eg, 2 days to 2 weeks) of disease signs and symptoms, long-term effectiveness, and treatments that were easy to prepare, use, and self-manage-oral or topical treatments were favored over injections, with the least favored being infusions. Low certainty evidence suggested that patients accepted minor feasibility burdens for rapid and sustained symptom relief but prioritized safety and tolerability as the risk or severity of adverse effects (eg, kidney injury, vomiting) increased. Conclusions and Relevance This systematic review suggests that patients with CU place high value on immediate and sustained hive, itch, and swelling relief, particularly long-term symptom-free periods, but may shift to prioritizing avoiding harms and burdens as the risk and severity of adverse effects increases. These findings may serve as a resource to improve the trustworthiness of recommendations and inform future CU management and research.

THE MAIN IDEA Podcast: Books for the Busy School Leader: THE MAIN IDEA Podcast: Books for the Busy School Leader

<p>Welcome to THE MAIN IDEA Podcast: Books for the Busy School Leader. I’m Jenn David-Lang, lifelong educator and creator of THE MAIN IDEA book summary service.</p><p><br /></p><p>My passion is helping school leaders learn. When leaders grow, the entire school community benefits.</p><p><br /></p><p>I know your time is limited. That’s why I read dozens of education and leadership books, select the most impactful, and distill them into clear, practical takeaways. </p><p><br /></p><p>Since 2007, I’ve been creating summaries for leaders around the world—and now, through this podc...

THE MAIN IDEA Podcast: Books for the Busy School Leader: Yes, Leaders Need Feedback, Too! Now AI Can Help with Andy Szeto

<p>School leaders know they need to ask for feedback. But when they do, how often does that feedback actually lead to meaningful change?</p><p><br></p><p>In this episode, Jenn David Lang is joined by Andy Szeto, professor of educational leadership, district leader in New York City, and former school leader. </p><p><br></p><p>Together, they unpack Andy’s recent Educational Leadership article, “Six Steps to Turn Qualitative Data into Actionable Insights,” and discuss how AI can support leaders in making sense of open-ended survey responses without losing the human element.</p><p><br></p><p>Andy’...

THE MAIN IDEA Podcast: Books for the Busy School Leader: Portrait of a Graduate: Preparing Students for Life After School with Lori McEwen

<p>What does it truly mean to prepare students for life beyond school — not just academically, but as thinkers, collaborators, empathetic people, and engaged citizens?</p><p>In this episode I (host Jenn David-Lang) am joined by education leader, researcher, and consultant Lori McEwen to unpack the concept of a Portrait of a Graduate (POG). </p><p>This portrait includes a set of skills that students must learn by the time they graduate in addition to the typical academic skills and content (skills like collaboration, communication, critical thinking, compassion, and creativity).</p><p>Lori explains what a portrait of a gra...

Interviews - David Lang

David Lang is one of the most thoughtful composers working today. His music is consistently probing, emotionally urgent, strange, and beautiful.

Blog | david-lang-celebrant

top of page. David Lang Marriage Celebrant & MC. HOME · SERVICES · HOW DOES IT WORK · ABOUT ME · THE DEAL · PHOTO/VIDEO · F.A.Q. · REVIEWS ...

User Profile: David Lang - Blogger

David Lang. My Photo. View Full Size. On Blogger since: February 2006. Profile views: 7,894. Report Abuse. My blogs. Better Bibles Blog · Accordance Blog.

About my blog - Down To Adventure

My name is David Lang and I'm always DTA: Down To Adventure. Welcome to my blog documenting all of my adventures, whether they be short, or long, risk ...

Down To Adventure

My name is David Lang and I'm always DTA: Down To Adventure. Welcome to my blog documenting all of my adventures, whether they be short, or long, risk ...