Health Optimization
Ketogenic Therapies and Fasting Mimics Show Promise for Alzheimer's, Cancer, and Metabolic Psychiatry
Ketogenic diets, exogenous ketones, and fasting-mimicking protocols like "sardine fasting" (low-calorie sardine intake) rescue brain glucose hypometabolism in Alzheimer's, termed "type 3 diabetes," by elevating beta-hydroxybutyrate levels (target GKI 1-2). These interventions reduce neuroinflammatio…
Sobriety, Metabolic Hacks, and Analog Revival: Ferriss and Rose on Health, AI Disruption, and Human Connection
Kevin Rose achieves 100 days alcohol-free, crediting health scares, peer support via 12-step networks, and daily reframing, yielding stable mood, weight loss, and relational improvements. Tim Ferriss reports peak lab results from 3-4 weeks ketosis followed by 16:8 intermittent fasting, zone 2 traini…
Multivitamins, Creatine, and HIIT: Low-Effort Interventions to Slow Cognitive and Cardiac Aging
Three RCTs show daily Centrum Silver multivitamins slow global cognitive aging by ~2 years and episodic memory aging by ~4.8 years in adults 65+ after 2 years. High-dose creatine (10-25g/day) counters sleep deprivation effects on cognition and boosts brain function via improved energy availability b…